Stem Cells Therapy for Spinal Cord Injury: An Overview of Clinical Trials.
Serena SilvestroPlacido BramantiOriana TrubianiEmanuela MazzonPublished in: International journal of molecular sciences (2020)
Spinal cord injury (SCI) is a traumatic lesion that causes disability with temporary or permanent sensory and/or motor deficits. The pharmacological approach still in use for the treatment of SCI involves the employment of corticosteroid drugs. However, SCI remains a very complex disorder that needs future studies to find effective pharmacological treatments. SCI actives a strong inflammatory response that induces a loss of neurons followed by a cascade of events that lead to further spinal cord damage. Many experimental studies demonstrate the therapeutic effect of stem cells in SCI due to their capacity to differentiate into neuronal cells and by releasing neurotrophic factors. Therefore, they appear to be a valid strategy to use in the field of regenerative medicine. The purpose of this paper is to provide an overview of clinical trials, recorded in clinical trial.gov during 2005-2019, aimed to evaluate the use of stem cell-based therapy in SCI. The results available thus far show the safety and efficacy of stem cell therapy in patients with SCI. However, future trials are needed to investigate the safety and efficacy of stem cell transplantation.
Keyphrases
- spinal cord injury
- stem cells
- spinal cord
- clinical trial
- cell therapy
- neuropathic pain
- stem cell transplantation
- inflammatory response
- high dose
- phase ii
- induced apoptosis
- current status
- traumatic brain injury
- oxidative stress
- open label
- cell proliferation
- endoplasmic reticulum stress
- randomized controlled trial
- lipopolysaccharide induced
- toll like receptor
- cell cycle arrest
- double blind
- multiple sclerosis
- brain injury
- phase iii
- replacement therapy
- cerebral ischemia
- signaling pathway