Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells.

Wentian SunYidan SongKai XiaLiyuan YuXinqi HuangZhihe ZhaoJun Liu

Published in: Stem cell research & therapy (2021)

The total m6A level was reduced with osteogenic differentiation of hASCs. The transcriptome-wide m6A methylome built in the present study indicated quite a few signaling pathways, and hub genes were influenced by m6A modification. Future studies based on these epigenetic clues could promote understanding of the mechanisms of osteogenic differentiation of hASCs.

Keyphrases

genome wide
gene expression
rna seq
dna methylation
single cell
endothelial cells
signaling pathway
bioinformatics analysis
induced pluripotent stem cells
current status
pluripotent stem cells
epithelial mesenchymal transition
pi k akt
endoplasmic reticulum stress