Effect of a DPP-4 Inhibitor on Orthodontic Tooth Movement and Associated Root Resorption.

Jiawei QiHideki KitauraWei-Ren ShenSaika OgawaFumitoshi OhoriTakahiro NoguchiAseel MarahlehYasuhiko NaraPramusita AdyaItaru Mizoguchi

Published in: BioMed research international (2020)

The DPP-4 inhibitor inhibited tooth movement and associated root resorption by blocking the formation of osteoclasts and odontoclasts, respectively. It also appeared to inhibit osteoclastogenesis and odontoclastogenesis by suppressing the expression of TNF-α and/or RANKL.

Keyphrases

bone loss
poor prognosis
rheumatoid arthritis
immune response
nuclear factor
inflammatory response