A multicentre and multi-national evaluation of the accuracy of quantitative Lu-177 SPECT/CT imaging performed within the MRTDosimetry project.
Johannes Tran-GiaAna M Denis-BacelarKelley M FerreiraAndrew P RobinsonNicholas CalvertAndrew J FenwickDomenico FinocchiaroFederica FioroniElisa GrassiWarda HeetunStephanie J JewittMaria KotzassarlidouMichael LjungbergDaniel R McGowanNathaniel ScottJames ScuffhamKatarina Sjögreen GleisnerJill TippingJill Wevrettnull nullMichael LassmannPublished in: EJNMMI physics (2021)
This international comparison exercise demonstrates that harmonization of quantitative SPECT/CT is feasible when following very specific instructions of a dedicated calibration protocol, as developed within the MRTDosimetry project. While quantitative imaging performance demonstrates significant harmonization, an over- and underestimation of the activity recovery highlights the limitations of any partial volume correction in the presence of spill-in and spill-out between two adjacent volumes of interests.