Associations between Bone Mineral Density and Longitudinal Changes of Vertebral Bone Marrow and Paraspinal Muscle Composition Assessed Using MR-Based Proton Density Fat Fraction and T2* Maps in Patients with and without Osteoporosis.
Florian Tilman GassertLeander GlanzChristof BoehmJonathan StelterFelix Gerhard GassertYannik LeonhardtGeorg C FeuerriegelMarkus GrafMarkus WurmThomas BaumRickmer F BrarenBenedikt J SchwaigerMarcus R MakowskiDimitrios C KarampinosAlexandra S GersingPublished in: Diagnostics (Basel, Switzerland) (2022)
The PSM CSA decreased significantly longitudinally in patients with osteoporosis/osteopenia, compared to those without. Additionally, higher vertebral and PSM PDFF at baseline were associated with stronger changes in vertebral bone marrow T2*. Therefore, longitudinal PDFF and T2* mapping may be useful quantitative radiation-free tools for the assessment and prediction of muscle and bone health in patients with suspected osteoporosis/osteopenia.