Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction.
Zeina R Al SayedRobin CanacBastien CimarostiCarine BonnardJean-Baptiste GourraudHanan HamamyHulya KayseriliAurore GirardeauMariam JouniNicolas JacobAnne GaignerieCaroline ChariauLaurent DavidVirginie ForestCéline MarionneauFlavien CharpentierGildas LoussouarnGuillaume LamiraultBruno ReversadeKazem ZibaraPatricia LemarchandNathalie GaboritPublished in: Cardiovascular research (2022)
Altogether, this work unveils a key role for IRX5 in the regulation of human ventricular depolarization and cardiac electrical conduction, providing therefore new insights into our understanding of cardiac diseases.