A case series of non-valvular cardiac aspergillosis in critically ill solid organ transplant and non-transplant patients and systematic review.
Annalan M D NavaratnamMohammad Al-FreahAnna CavazzaGeorg AuzingerPublished in: Journal of the Intensive Care Society (2020)
Antemortem diagnosis of cardiac aspergillosis is difficult and rare, with no cases reporting positive blood culture results. Galactomannan serology has poor sensitivity in solid organ transplant patients, further reduced by prophylactic antimicrobial treatment, which is common in the ICU setting especially post-transplant patients. Due to the scarcity of cases, treatment is extrapolated from invasive aspergillosis management, with emphasis on early treatment with combination therapy.
Keyphrases
- end stage renal disease
- combination therapy
- systematic review
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- emergency department
- intensive care unit
- heart failure
- staphylococcus aureus
- randomized controlled trial
- meta analyses
- aortic valve
- adverse drug
- mechanical ventilation
- drug induced