RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia.

Govardhan AnandeNandan P DeshpandeSylvain MareschalAarif M N BatchaHenry R HamptonTobias HeroldSoren LehmannMarc R WilkinsJason W H WongAshwin UnnikrishnanJohn E Pimanda

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Our discoveries therefore identify aberrant alternative splicing as a molecular feature of adverse AML with clinical relevance.See related commentary by Bowman, p. 3503.

Keyphrases

poor prognosis
long non coding rna
acute myeloid leukemia
machine learning
deep learning
allogeneic hematopoietic stem cell transplantation
single molecule
acute lymphoblastic leukemia
nucleic acid
electronic health record