Safety and Effectiveness of Antidysrhythmic Drugs for Pharmacologic Cardioversion of Recent-Onset Atrial Fibrillation: a Systematic Review and Bayesian Network Meta-analysis.
Ian S deSouzaPragati ShresthaRobert AllenJessica KoosHenry ThodePublished in: Cardiovascular drugs and therapy (2024)
Among guideline-recommended antidysrhythmic drugs, the combination of digoxin IV and amiodarone IV is definitely among the least safe for cardioversion of recent onset AF; flecainide, vernakalant, ibutilide, propafenone, and amiodarone IV are definitely among the most effective for cardioversion within 4 h; flecainide is definitely among the most effective for cardioversion within 24 h. Further, randomized controlled trials with predetermined and strictly defined, hemodynamic adverse event outcomes are recommended.
Keyphrases
- study protocol
- atrial fibrillation
- randomized controlled trial
- systematic review
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- meta analyses
- direct oral anticoagulants
- clinical trial
- heart failure
- percutaneous coronary intervention
- emergency department
- coronary artery disease
- acute coronary syndrome
- adipose tissue