Estimation of vaccine effectiveness against SARS-CoV-2-associated hospitalization using sentinel surveillance in South Africa.
Nicola ChiwandireSibongile WalazaAnne von GottbergNicole WolterMignon Du PlessisFahima MoosaMichelle J GroomeJeremy NelEbrahim VariavaHalima DawoodMvuyo MakhasiLeora R FeldsteinPerrine MarcenacKathryn E LafondAaron M SamuelsCheryl CohenPublished in: International journal of epidemiology (2024)
The BNT162b2 vaccine was effective against SARS-CoV-2-associated hospitalization during the Delta period for adults aged ≥18 years, ≥60 years and those HIV-uninfected. VE for Ad26.COV2.S was inconclusive, potentially due to limited sample size or residual confounding. These findings highlight the utility of sentinel surveillance for estimating VE.