Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Huijuan DouAndriana G KotiniWenli LiuTrevor FidlerKaori Endo UmedaXiaoli SunMalgorzata OlszewskaTong XiaoSandra AbramowiczMustafa YalcinkayaBrian HardawaySotirios TsimikasXuchu QueAlexander G BickConnor A EmdinPradeep NatarajanEirini P PapapetrouJoseph L WitztumNan WangAlan R TallPublished in: Circulation (2021)
Hematopoietic Lnk deficiency promotes NETosis and arterial thrombosis in an OxPL-dependent fashion. LNK(R262W) reduces LNK function in human platelets and neutrophils promoting NETosis, and increases CAD risk in humans carrying JAK2VF mutations. Therapies targeting OxPL may be beneficial for CAD in genetically defined human populations.