1'-Acetoxychavicol acetate, a potent transient receptor potential ankyrin 1 agonist derived from Thai ginger, prevents visceral fat accumulation in mice fed with a high-fat and high-sucrose diet.
Tatsunori IkeyaYuko TeradaYasujiro MorimitsuKikue KubotaKeisuke ItoTatsuo WatanabePublished in: Bioscience, biotechnology, and biochemistry (2021)
1'-Acetoxychavicol acetate (ACA) is found in Thai ginger (Alpinia galanga) and is a powerful agonist of transient receptor potential ankyrin 1 (TRPA1). In a diet-induced obesity mouse model, ACA reduced fat deposition. Sympathetic nerve activation was also indicated in the ACA-fed group. This study is expected to promote the utilization of food containing TRPA1 agonists to treat obesity.
Keyphrases
- high fat diet induced
- insulin resistance
- weight loss
- mouse model
- adipose tissue
- metabolic syndrome
- type diabetes
- human health
- affordable care act
- weight gain
- cerebral ischemia
- fatty acid
- skeletal muscle
- physical activity
- binding protein
- anti inflammatory
- body mass index
- peripheral nerve
- blood brain barrier
- brain injury