Efficacy and Safety of Oral Factor XIa Inhibitors in Stroke Prevention: A Systematic Review and Meta-Analysis.
Lina PalaiodimouGeorgia PapagiannopoulouAristeidis H KatsanosAndreas EleftheriouTheodoros KarapanayiotidesPanayiotis D MitsiasRobin LemmensCarlos A MolinaAndrei AlexandrovValeria CasoAshkan ShoamaneshMukul SharmaGeorgios TsivgoulisPublished in: Journal of clinical medicine (2023)
This meta-analysis provides reassuring evidence regarding the safety of factor XIa inhibitors. These findings, coupled with potential signals of efficacy in reducing IS (and TIA), underscore the importance of ongoing phase III RCTs for providing definitive data regarding the effect of factor XIa inhibition on stroke prevention.
Keyphrases
- phase iii
- systematic review
- atrial fibrillation
- clinical trial
- open label
- squamous cell carcinoma
- randomized controlled trial
- meta analyses
- phase ii
- double blind
- big data
- cerebral ischemia
- risk assessment
- placebo controlled
- deep learning
- human health
- climate change
- brain injury
- study protocol
- rectal cancer
- subarachnoid hemorrhage
- case control