The Role of Non-Coding RNAs in Myelodysplastic Neoplasms.
Vasileios GeorgoulisEpameinondas KoumpisEleftheria HatzimichaelPublished in: Cancers (2023)
Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or therapeutic targets in MDS.
Keyphrases
- acute myeloid leukemia
- long non coding rna
- peripheral blood
- allogeneic hematopoietic stem cell transplantation
- poor prognosis
- bone marrow
- single cell
- cell therapy
- transcription factor
- stem cells
- human health
- mesenchymal stem cells
- dendritic cells
- risk assessment
- acute lymphoblastic leukemia
- hyaluronic acid
- climate change
- solid state