The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma.
Jorge Melendez-ZajglaVilma MaldonadoPublished in: International journal of molecular sciences (2021)
Pancreatic ductal adenocarcinoma is one of the deadliest tumors. This neoplasia is characterized by an important cellular and phenotypic heterogeneity. In particular, it has been shown that at least two subtypes can be found: basal-like, which presents stem-like properties, and classical. Cancer stem cells have been isolated and characterized from these tumors, showing their dependance on general and tissue-specific stem transcription factors and signaling pathways. Nevertheless, little is known about their tissue microenvironment and cell non-autonomous regulators, such as long-non-coding RNAs. (lncRNAs). In this review, we summarize the current knowledge about the positive and negative effects of lncRNAs in the stemness phenotype of pancreatic ductal adenocarcinoma cancer (PDAC).
Keyphrases
- cancer stem cells
- long non coding rna
- transcription factor
- stem cells
- genome wide identification
- single cell
- poor prognosis
- network analysis
- signaling pathway
- papillary thyroid
- healthcare
- epithelial mesenchymal transition
- genome wide analysis
- cell therapy
- high grade
- squamous cell
- squamous cell carcinoma
- pi k akt
- induced apoptosis
- mesenchymal stem cells
- bone marrow