Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE2 pathway.

Anping PengXinyi LuJun HuangMin HeJianhua XuHui HuangQubo Chen

Published in: Arthritis research & therapy (2019)

Our data is the first report to reveal the critical role of RASF in upregulating TREM-1 expression in monocytes, which indicates that TREM-1 might be a novel target for RA therapy.

Keyphrases

rheumatoid arthritis
poor prognosis
disease activity
dendritic cells
peripheral blood
binding protein
ankylosing spondylitis
interstitial lung disease
genome wide
gene expression
systemic lupus erythematosus
single cell
big data
extracellular matrix
bone marrow
smoking cessation