Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes.
Rasmus J O SjögrenDavid Rizo-RocaAlexander V ChibalinElin ChorellRegula FurrerShintaro KatayamaJun HaradaHåkan K R KarlssonChristoph HandschinThomas MoritzAnna KrookErik NäslundJuleen R ZierathPublished in: Diabetologia (2021)
Metabolic inflexibility in type 2 diabetes impacts BCAA homeostasis and attenuates the decrease in circulating and skeletal muscle BCAA-related metabolites after a glucose challenge. Transcriptional regulation of BCAA genes in primary human myotubes via PGC-1α is ERRα-dependent.