Safety and efficacy of tuberculosis vaccine candidates in low- and middle-income countries: a systematic review of randomised controlled clinical trials.

Lydia WilsonLara GracieFarah KidyG Neil ThomasKrishnarajah NirantharakumarSheila GreenfieldSemira Manaseki-HollandDerek J WardTiffany E Gooden

Published in: BMC infectious diseases (2023)

Further efficacy trials for M72/AS01 are warranted to include additional populations at risk where safety has been demonstrated. Further safety trials are needed for the remaining vaccine candidates to confirm safety in vulnerable populations.

Keyphrases

clinical trial
mycobacterium tuberculosis
randomized controlled trial
pulmonary tuberculosis
phase ii
hiv infected
open label
phase iii