Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.
Eline J M BertrumsAxel K M Rosendahl HuberJurrian K de KanterArianne M BrandsmaAnaïs J C N van LeeuwenMark VerheulMarry M M van den Heuvel-EibrinkRurika OkaMarkus J van RoosmalenHester A de Groot-KrusemanChristian Michel ZwaanBianca Frederika GoemansRuben van BoxtelPublished in: Cancer discovery (2022)
Our study shows that chemotherapy increases the mutation burden of normal blood cells in cancer survivors. Only few drugs damage the DNA directly, whereas in most patients, chemotherapy-induced mutations are caused by processes similar to those present during normal aging. This article is highlighted in the In This Issue feature, p. 1825.
Keyphrases
- chemotherapy induced
- end stage renal disease
- young adults
- newly diagnosed
- ejection fraction
- induced apoptosis
- chronic kidney disease
- papillary thyroid
- machine learning
- peritoneal dialysis
- bone marrow
- stem cells
- deep learning
- dendritic cells
- childhood cancer
- squamous cell carcinoma
- single molecule
- circulating tumor
- radiation therapy
- cell free
- squamous cell
- signaling pathway
- neural network