Ruben van Boxtel (R van Boxtel)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 34

Top Venues

Nature communications

Nature genetics

Cancer research

Nature

Princess Máxima Center for Pediatric Oncology

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Princess Máxima Center for Pediatric Oncology Sep 01 2017

Netherlands

Principle Investigator

Publications

Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie C Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer. Nature genetics 56 (7) (2024)
Vera M Poort, Rico Hagelaar, Markus J van Roosmalen, Laurianne Trabut, Jessica G C A M Buijs-Gladdines, Bram van Wijk, Jules P P Meijerink, Ruben van Boxtel
Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation. Cancer research 84 (16) (2024)
Eline J M Bertrums, Jurrian K de Kanter, Lucca L M Derks, Mark Verheul, Laurianne Trabut, Markus J van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N Dworzak, Nora Mühlegger, Marry M M van den Heuvel-Eibrink, C Michel Zwaan, Bianca Frederika Goemans, Ruben van Boxtel
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms. Nature communications 15 (1) (2024)
Vera M Poort, Rico Hagelaar, Markus J van Roosmalen, Laurianne Trabut, Jessica G C A M Buijs-Gladdines, Bram van Wijk, Jules P P Meijerink, Ruben van Boxtel
Transient Differentiation-State Plasticity Occurs During Acute Lymphoblastic Leukemia Initiation. Cancer research (2024)
Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie C Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer. Nature genetics (2024)
Daan M K van Soest, Paulien E Polderman, Wytze T F den Toom, Janneke P Keijer, Markus J van Roosmalen, Tim M F Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn M T Burgering, Tobias B Dansen
Mitochondrial H 2 O 2 release does not directly cause damage to chromosomal DNA. Nature communications 15 (1) (2024)
Eline J M Bertrums, Jurrian K de Kanter, Lucca L M Derks, Mark Verheul, Laurianne Trabut, Markus J van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N Dworzak, Nora Mühlegger, Marry M M van den Heuvel-Eibrink, C Michel Zwaan, Bianca Frederika Goemans, Ruben van Boxtel
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms. Nature communications 15 (1) (2024)
Eline J M Bertrums, Jurrian K de Kanter, Lucca L M Derks, Mark Verheul, Laurianne Trabut, Markus J van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael N Dworzak, Nora Mühlegger, Marry M M van den Heuvel-Eibrink, C Michel Zwaan, Bianca Frederika Goemans, Ruben van Boxtel
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms. Nature communications 15 (1) (2024)
Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie C Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer. Nature genetics 56 (7) (2024)
Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie C Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer. Nature genetics 56 (7) (2024)
Vera M Poort, Rico Hagelaar, Markus J van Roosmalen, Laurianne Trabut, Jessica G C A M Buijs-Gladdines, Bram van Wijk, Jules P P Meijerink, Ruben van Boxtel
Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation. Cancer research 84 (16) (2024)
Vera M Poort, Rico Hagelaar, Markus J van Roosmalen, Laurianne Trabut, Jessica G C A M Buijs-Gladdines, Bram van Wijk, Jules P P Meijerink, Ruben van Boxtel
Transient Differentiation-State Plasticity Occurs during Acute Lymphoblastic Leukemia Initiation. Cancer research 84 (16) (2024)
Daan M K van Soest, Paulien E Polderman, Wytze T F den Toom, Janneke P Keijer, Markus J van Roosmalen, Tim M F Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn M T Burgering, Tobias B Dansen
Mitochondrial H 2 O 2 release does not directly cause damage to chromosomal DNA. Nature communications 15 (1) (2024)
Hamzeh Kayhanian, William Cross, Suzanne E M van der Horst, Panagiotis Barmpoutis, Eszter Lakatos, Giulio Caravagna, Luis Zapata, Arne Van Hoeck, Sjors Middelkamp, Kevin Litchfield, Christopher Steele, William Waddingham, Dominic Patel, Salvatore Milite, Chen Jin, Ann-Marie C Baker, Daniel C Alexander, Khurum Khan, Daniel Hochhauser, Marco Novelli, Benjamin Werner, Ruben van Boxtel, Joris H Hageman, Julian R Buissant des Amorie, Josep Linares, Marjolijn J L Ligtenberg, Iris D Nagtegaal, Miangela M Laclé, Leon M G Moons, Lodewijk A A Brosens, Nischalan Pillay, Andrea Sottoriva, Trevor A Graham, Manuel Rodriguez, Kai-Keen Shiu, Hugo J G Snippert, Marnix Jansen
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer. Nature genetics 56 (7) (2024)
Daan M K van Soest, Paulien E Polderman, Wytze T F den Toom, Janneke P Keijer, Markus J van Roosmalen, Tim M F Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn M T Burgering, Tobias B Dansen
Mitochondrial H 2 O 2 release does not directly cause damage to chromosomal DNA. Nature communications 15 (1) (2024)
Maarten H Geurts, Shashank Gandhi, Matteo G Boretto, Ninouk Akkerman, Lucca L M Derks, Gijs J F van Son, Martina Celotti, Sarina Harshuk-Shabso, Flavia Peci, Harry Begthel, Delilah Hendriks, Paul Schürmann, Amanda Andersson-Rolf, Susana M Chuva de Sousa Lopes, Johan H van Es, Ruben van Boxtel, Hans Clevers
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids. Nature communications 14 (1) (2023)
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K de Kanter, Yannick P Kok, Marieke Everts, H Rudolf de Boer, Anastasia Audrey, Femke J Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana Carolina Johanna Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M Lansdorp, Marcel A T M van Vugt
Sister chromatid exchanges induced by perturbed replication can form independently of BRCA1, BRCA2 and RAD51. Nature communications 13 (1) (2022)
Marlinde L van den Boogaard, Rurika Oka, Anne Hakkert, Linda Schild, Marli E Ebus, Michael R van Gerven, Danny A Zwijnenburg, Piet Molenaar, Lieke L Hoyng, M Emmy M Dolman, Anke H W Essing, Bianca Koopmans, Thomas Helleday, Jarno Drost, Ruben van Boxtel, Rogier Versteeg, Jan Koster, Jan J Molenaar
Defects in 8-oxo-guanine repair pathway cause high frequency of C > A substitutions in neuroblastoma. Proceedings of the National Academy of Sciences of the United States of America 118 (36) (2022)
Eline J M Bertrums, Axel K M Rosendahl Huber, Jurrian K de Kanter, Arianne M Brandsma, Anaïs J C N van Leeuwen, Mark Verheul, Marry M M van den Heuvel-Eibrink, Rurika Oka, Markus J van Roosmalen, Hester A de Groot-Kruseman, Christian Michel Zwaan, Bianca Frederika Goemans, Ruben van Boxtel
Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms. Cancer discovery 12 (8) (2022)
Maria Vougioukalaki, Joris Demmers, Wilbert P Vermeij, Marjolein Baar, Serena Bruens, Aristea Magaraki, Ewart W Kuijk, Myrthe Jager, Sarra Merzouk, Renata M C Brandt, Janneke Kouwenberg, Ruben van Boxtel, Edwin Cuppen, Joris Pothof, Jan H J Hoeijmakers
Different responses to DNA damage determine ageing differences between organs. Aging cell 21 (4) (2022)
Freek Manders, Arianne M Brandsma, Jurrian K de Kanter, Mark Verheul, Rurika Oka, Markus J van Roosmalen, Bastiaan R Van der Roest, Arne Van Hoeck, Edwin Cuppen, Ruben van Boxtel
MutationalPatterns: the one stop shop for the analysis of mutational processes. BMC genomics 23 (1) (2022)
K A L Hasaart, E J M Bertrums, F Manders, B F Goemans, Ruben van Boxtel
Increased risk of leukaemia in children with Down syndrome: a somatic evolutionary view. Expert reviews in molecular medicine 23 (2021)
Lukas Villiger, Tanja Rothgangl, Dominik Witzigmann, Rurika Oka, Paulo J C Lin, Weihong Qi, Sharan Janjuha, Christian Berk, Femke Ringnalda, Mitchell B Beattie, Markus Stoffel, Beat Thöny, Jonathan Hall, Hubert Rehrauer, Ruben van Boxtel, Ying K Tam, Gerald Schwank
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA. Nature biomedical engineering 5 (2) (2021)
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E de Ruiter, Mauro D Locati, Nicolle J M Besselink, Bastiaan R Van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan Nicolaas Maria IJzermans, Michael Doukas, Monique M A Verstegen, Ruben van Boxtel, Luc J W van der Laan, Edwin Cuppen, Ewart W Kuijk
Precancerous liver diseases do not cause increased mutagenesis in liver stem cells. Communications biology 4 (1) (2021)
Luiza Moore, Alex T J Cagan, Tim H H Coorens, Matthew D C Neville, Rashesh Sanghvi, Mathijs A Sanders, Thomas Richard William Oliver, Daniel A Leongamornlert, Peter Ellis, Ayesha Noorani, Thomas J Mitchell, Timothy M Butler, Yvette Hooks, Anne Y Warren, Mette Jorgensen, Kevin J Dawson, Andrew Menzies, Laura O'Neill, Calli Latimer, Mabel Teng, Ruben van Boxtel, Christine A Iacobuzio-Donahue, Iñigo Martincorena, Rakesh Heer, Peter J Campbell, Rebecca C Fitzgerald, Michael R Stratton, Raheleh Rahbari
The mutational landscape of human somatic and germline cells. Nature 597 (7876) (2021)
Georg A Busslinger, Buys de Barbanson, Rurika Oka, Bas L A Weusten, Michiel de Maat, Richard van Hillegersberg, Lodewijk A A Brosens, Ruben van Boxtel, Alexander van Oudenaarden, Hans Clevers
Molecular characterization of Barrett's esophagus at single-cell resolution. Proceedings of the National Academy of Sciences of the United States of America 118 (47) (2021)
Tanja Rothgangl, Melissa K Dennis, Paulo J C Lin, Rurika Oka, Dominik Witzigmann, Lukas Villiger, Weihong Qi, Martina Hruzova, Lucas Kissling, Daniela Lenggenhager, Costanza Borrelli, Sabina Egli, Nina Frey, Noëlle Bakker, John A Walker, Anastasia P Kadina, Denis V Victorov, Martin Pacesa, Susanne Kreutzer, Zacharias Kontarakis, Andreas E Moor, Martin Jinek, Drew Weissman, Markus Stoffel, Ruben van Boxtel, Kevin Holden, Norbert Pardi, Beat Thöny, Johannes Häberle, Ying K Tam, Sean C Semple, Gerald Schwank
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels. Nature biotechnology 39 (8) (2021)
Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel Rosendahl Huber, Arne Van Hoeck, Henry M Wood, Jason Nomburg, Carino Gurjao, Freek Manders, Guillaume Dalmasso, Paul B Stege, Fernanda L Paganelli, Maarten H Geurts, Joep Beumer, Tomohiro Mizutani, Yi Miao, Reinier van der Linden, Stefan van der Elst, null null, K Christopher Garcia, Janetta Top, Rob J L Willems, Marios Giannakis, Richard Bonnet, Philip Quirke, Matthew L Meyerson, Edwin Cuppen, Ruben van Boxtel, Hans Clevers
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature 580 (7802) (2020)
Camilla Calandrini, Frans Schutgens, Rurika Oka, Thanasis Margaritis, Tito Candelli, Luka Mathijsen, Carola Ammerlaan, Ravian L van Ineveld, Sepide Derakhshan, Sanne de Haan, Emmy Dolman, Philip Lijnzaad, Lars Custers, Harry Begthel, Hindrik H D Kerstens, Lindy L Visser, Maarten Rookmaaker, Marianne Christina Verhaar, Godelieve A M Tytgat, Patrick Kemmeren, Ronald R de Krijger, Reem Al-Saadi, Kathy Pritchard-Jones, Marcel Kool, Anne C Rios, Marry M van den Heuvel-Eibrink, Jan J Molenaar, Ruben van Boxtel, Frank C P Holstege, Hans Clevers, Jarno Drost
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nature communications 11 (1) (2020)
Ewart W Kuijk, Myrthe Jager, Bastiaan R Van der Roest, Mauro D Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle J M Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
The mutational impact of culturing human pluripotent and adult stem cells. Nature communications 11 (1) (2020)
Imre F Schene, Indi P Joore, Rurika Oka, Michal Mokry, Anke H M van Vugt, Ruben van Boxtel, Hubert P J van der Doef, Luc J W van der Laan, Monique M A Verstegen, Peter M van Hasselt, Edward E S Nieuwenhuis, Sabine A Fuchs
Prime editing for functional repair in patient-derived disease models. Nature communications 11 (1) (2020)
Ewart W Kuijk, Myrthe Jager, Bastiaan R Van der Roest, Mauro D Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle J M Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells. Nature communications 11 (1) (2020)
Ewart W Kuijk, Francis Blokzijl, Myrthe Jager, Nicolle Besselink, Sander Boymans, Susana M Chuva de Sousa Lopes, Ruben van Boxtel, Edwin Cuppen
Early divergence of mutational processes in human fetal tissues. Science advances 5 (5) (2019)
Jarno Drost, Ruben van Boxtel, Francis Blokzijl, Tomohiro Mizutani, Nobuo Sasaki, Valentina Sasselli, Joep de Ligt, Sam Behjati, Judith E Grolleman, J Tom van Wezel, Serena Nik-Zainal, Roland P Kuiper, Edwin Cuppen, Hans Clevers
Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science (New York, N.Y.) 358 (6360) (2017)

Ruben van Boxtel (R van Boxtel)

Publication Activity (10 Years)

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