Nickel-Catalyzed Three-Component Cross-Electrophile Coupling of 1,3-Dienes with Aldehydes and Aryl Bromides.

Ya-Qiong QiShuai LiuYan XuYang LiTong SuHai-Liang NiYuanji GaoWenhao YuPeng CaoPing HuKe-Qing ZhaoBi-Qin WangBin Chen

Published in: Organic letters (2022)

We herein report a Ni-catalyzed three-component cross-electrophile coupling of 1,3-dienes with aldehydes and aryl bromides using manganese metal as the reducing agent. This efficient protocol accomplishes dicarbofunctionalization of 1,3-dienes to synthesize diverse structural 1,4-disubstituted homoallylic alcohols by forming two new C-C bonds in one time. Mechanistic study suggests that an allyl-nickel(I) species is involved in the catalytic cycle.

Keyphrases

room temperature
oxide nanoparticles
metal organic framework
randomized controlled trial
reduced graphene oxide
carbon nanotubes
transition metal