Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma.

Fabienne DesmotsMikaël RousselCéline PangaultFrancisco Llamas-GutierrezCédric PastoretEric GuiheneufJérôme Le PriolValérie Camara-ClayetteGersende CaronCatherine HenryMarc-Antoine Belaud-RotureauPascal GodmerThierry LamyFabrice JardinKarin TarteVincent RibragThierry Fest

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Our data uncover a new mechanism by which pan-HDAC inhibitors may act positively to treat patients with follicular lymphoma through the induction of the expression of plasma cell genes.

Keyphrases

histone deacetylase
poor prognosis
single cell
genome wide

cell therapy
electronic health record
big data
stem cells

gene expression
dna methylation
mesenchymal stem cells

genome wide identification
bioinformatics analysis
data analysis