Pan-HDAC Inhibitors Restore PRDM1 Response to IL21 in CREBBP-Mutated Follicular Lymphoma.
Fabienne DesmotsMikaël RousselCéline PangaultFrancisco Llamas-GutierrezCédric PastoretEric GuiheneufJérôme Le PriolValérie Camara-ClayetteGersende CaronCatherine HenryMarc-Antoine Belaud-RotureauPascal GodmerThierry LamyFabrice JardinKarin TarteVincent RibragThierry FestPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Our data uncover a new mechanism by which pan-HDAC inhibitors may act positively to treat patients with follicular lymphoma through the induction of the expression of plasma cell genes.