FoxP3+ CXCR5+ CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome.
M IvanchenkoL A AqrawiA BjörkMarie Wahren-HerleniusK CheminPublished in: Clinical and experimental immunology (2019)
We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sjögren's syndrome (SS). Here we investigated the frequency of CD25+ FoxP3+ CD4+ regulatory T cells (Tregs ) among CXCR5+ CD4+ follicular cells in the same cohort of patients. We confirm that the frequency of Tregs among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5+ FoxP3+ CD4+ T cells.
Keyphrases
- regulatory t cells
- peripheral blood
- end stage renal disease
- chronic kidney disease
- ejection fraction
- induced apoptosis
- dendritic cells
- newly diagnosed
- peritoneal dialysis
- poor prognosis
- prognostic factors
- case report
- machine learning
- oxidative stress
- deep learning
- systemic lupus erythematosus
- disease activity
- cell proliferation
- immune response
- nk cells
- cell death
- high resolution
- atomic force microscopy
- high speed
- data analysis