A two-state model for the kinetics of competitive radioligand binding.

Dong GuoLambertus A PeletierLloyd BridgeWesley KeurHenk de VriesAnnelien ZweemerLaura H HeitmanAdriaan P IJzerman

Published in: British journal of pharmacology (2018)

The two-state model is sufficient to analyse the binding kinetics of an unlabelled ligand, when a radioligand shows biphasic association characteristics. We expect this two-state model to have general applicability for other targets as well.

Keyphrases

binding protein