Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen-Activated Protein Kinase Kinase 6-Dependent p38 Mitogen-Activated Protein Kinase Signaling to Drive Hepatocarcinogenesis.
Steve T LukKai-Yu NgLei ZhouMan TongTin-Lok WongHuajian YuChung-Mau LoKwan ManXin-Yuan GuanTerence Kin-Wah LeeStephianie MaPublished in: Hepatology (Baltimore, Md.) (2020)
Our work describes a critical repressive function of REX1 in maintenance of HCC cells by regulating MKK6 binding and p38 MAPK signaling. REX1 deficiency induced enhancement of p38 MAPK signaling, leading to F-actin reorganization and activation of nuclear factor erythroid 2-related factor 2-mediated oxidative stress response, which collectively contributed to enhanced stemness and metastatic capabilities of HCC cells.
Keyphrases
- stem cells
- induced apoptosis
- nuclear factor
- cell cycle arrest
- protein kinase
- tyrosine kinase
- toll like receptor
- small cell lung cancer
- poor prognosis
- squamous cell carcinoma
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- high glucose
- cell proliferation
- inflammatory response
- replacement therapy
- drug induced
- mesenchymal stem cells