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Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1.

Wenjun PuZeyad D NassarSamira KhabbaziNan XieKerrie-Ann McMahonRobert G PartonGregory J RigginsJonathan M HarrisMarie-Odile Parat
Published in: Journal of neuro-oncology (2019)
Expression of both caveolin-1 and CAVIN1 was increased in GBM compared to normal samples and correlated with expression of urokinase plasminogen activator (uPA) and gelatinases. High expression of caveola-forming proteins was associated with shorter survival time. GBM cell lines capable of forming caveolae expressed more uPA and matrix metalloproteinase-2 (MMP-2) and/or -9 (MMP-9) and were more invasive than GBM cells devoid of caveola-forming proteins. Experimental manipulation of caveolin-1 or CAVIN1 expression in GBM cells recapitulated some, but not all of these features. Caveolae modulate GBM cell invasion in part via matrix protease expression.
Keyphrases
  • poor prognosis
  • binding protein
  • induced apoptosis
  • long non coding rna
  • cell cycle arrest