Upregulation of Transferrin Receptor 1 (TfR1) but Not Glucose Transporter 1 (GLUT1) or CD98hc at the Blood-Brain Barrier in Response to Valproic Acid.

Steinunn Sara HelgudottirKasper Bendix JohnsenLisa Greve RoutheCharlotte Laurfelt Munch RasmussenMaj Schneider Thomsen Torben Moos

Published in: Cells (2024)

VPA upregulates TfR1 in brain endothelium in vivo and in vitro. VPA does not increase GLUT1 and CD98hc proteins. The increase in TfR1 does not result in higher anti-TfR1 antibody targetability, suggesting targeting sufficiently occurs with available transferrin receptors without further contribution from accessory VPA-induced TfR1.

Keyphrases

nitric oxide
cell proliferation
high glucose
poor prognosis
signaling pathway
white matter
resting state
type diabetes
nk cells
cancer therapy
metabolic syndrome
multiple sclerosis
functional connectivity
drug induced
long non coding rna
stress induced