Hypophysitis, Panhypopituitarism, and Hypothalamitis in a Scottish Terrier Dog.
Laura PolledoM OliveiraJ AdamanyP GrahamK BaikerPublished in: Journal of veterinary internal medicine (2017)
A 6-year old male neutered Scottish Terrier was referred with a 1 week history of progressive lethargy and anorexia. Neurological examination localized a lesion to the forebrain and hormonal testing showed panhypopituitarism. Magnetic resonance imaging (MRI) of the brain revealed a rounded, well-defined, suprasellar central mass. The mass was slightly hyperintense to the cortical grey matter on T2-weighted (T2W), hypointense on T1-weighted (T1W) images and without T2* signal void. There was a central fusiform enhancement of the mass after contrast administration which raised the suspicion of a pituitary neoplasm. Rapid deterioration of the dog prevented further clinical investigations. Histopathologic examination revealed a lymphocytic panhypophysitis of unknown origin suspected autoimmune involving the hypothalamus (hypothalamitis). This is a unique case report of a dog presenting with inflammatory hypophysitis and hypothalamitis of suspected autoimmune origin with detailed clinical, MRI, histology and immunohistochemistry findings.
Keyphrases
- contrast enhanced
- magnetic resonance imaging
- case report
- magnetic resonance
- multiple sclerosis
- computed tomography
- diffusion weighted imaging
- white matter
- pulmonary embolism
- deep learning
- oxidative stress
- convolutional neural network
- randomized controlled trial
- optical coherence tomography
- machine learning
- drug induced
- network analysis
- metabolic syndrome
- high grade
- study protocol
- growth hormone
- sensitive detection
- placebo controlled