Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846.

Teppei SuganoMari MasudaFumitaka TakeshitaNoriko MotoiToru HirozaneNaoko GotoShigeki KashimotoYuko UnoHideki MoriyamaMasaaki SawaYuichi NagakawaAkihiko TsuchidaMasahiro SeikeAkihiko GemmaTesshi Yamada

Published in: British journal of cancer (2020)

NCB-0846 pharmacologically blocks the TGFβ/SMAD signalling and EMT induction of lung cancer cells by transcriptionally downregulating TGFBRI expression, representing a potentially promising approach for prevention of metastasis in lung cancer patients.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
poor prognosis
signaling pathway
long non coding rna
protein kinase