A Pilot Analysis of Genome-Wide DNA Methylation Patterns in Mouse Cartilage Reveals Overlapping Epigenetic Signatures of Aging and Osteoarthritis.
Vladislav IzdaChristopher M DunnEmmaline PrinzLeoni SchluppEmily NguyenCassandra SturdyMatlock A JeffriesPublished in: ACR open rheumatology (2022)
Aging and early OA following DMM surgery induce similar DNA methylation changes within a murine OA model, suggesting that aging may induce pro-OA epigenetic "poising" within articular cartilage. Future research should focus on confirming and expanding these findings to other environmental OA risk factors, including obesity, as well as determining late OA changes in mice.
Keyphrases
- dna methylation
- genome wide
- knee osteoarthritis
- gene expression
- risk factors
- high fat diet induced
- copy number
- minimally invasive
- insulin resistance
- metabolic syndrome
- type diabetes
- rheumatoid arthritis
- weight loss
- randomized controlled trial
- clinical trial
- study protocol
- coronary artery bypass
- coronary artery disease
- climate change
- body mass index
- risk assessment
- acute coronary syndrome
- anti inflammatory
- physical activity
- life cycle