In Vitro Screening and Transfection Concentration Optimization of Cynomolgus Monkey IκBα-siRNA.

Zhaoxing OuRui ZengYifan LinSi ZhangMohammad Alzogool Peng Zeng Yuqing Lan

Published in: Journal of ophthalmology (2020)

It proves that the siRNA targeting the GCACTTAGCCTCTATCCAT of IκBα gene is the valid sequence to suppress cynomolgus monkey IκBα expression of CM cells and TM cells by RNAi. 10 nM is the optimal transfection concentration.

Keyphrases

induced apoptosis
cell cycle arrest
cancer therapy
poor prognosis
endoplasmic reticulum stress
cell death
oxidative stress
photodynamic therapy
gene expression
drug delivery
genome wide