Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia.

Wataru ArihisaTakeshi KondoKatsushi YamaguchiJunya MatsumotoHiroki NakanishiYasuto KuniiHiroyasu AkatsuMizuki HinoYoshio HashizumeShumpei SatoShinji SatoShin-Ichi NiwaHirooki YabeTakehiko SasakiShuji ShigenobuMitsutoshi Setou

Published in: Neuropsychopharmacology reports (2023)

This study provided results of the integrated analysis of the schizophrenia-associated transcriptome and lipidome within the PFC and revealed that lipid-correlated alterations in the transcriptome are enriched in specific pathways including ether lipid metabolism pathway.

Keyphrases

single cell
rna seq
prefrontal cortex
genome wide
gene expression
fatty acid
bipolar disorder
ionic liquid