Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway.

Ang ZhengXinyue SongLin ZhangLin ZhaoXiaoyun MaoMinjie WeiFeng Jin

Published in: Journal of experimental & clinical cancer research : CR (2019)

LUCAT1 might be a significant biomarker to evaluate prognosis in breast cancer. LUCAT1 increased stem-like properties of BCCs and stemness of BCSCs by competitively binding miR-5582-3p with TCF7L2 and enhancing the Wnt/β-catenin pathway. The LUCAT1/miR-5582-3p/TCF7L2 axis provides insights for regulatory mechanism of stemness, and new strategies for clinical practice.

Keyphrases

long non coding rna
stem cells
epithelial mesenchymal transition
poor prognosis
clinical practice
cell proliferation
transcription factor
dna binding
breast cancer risk
signaling pathway
binding protein