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Vancomycin Pharmacokinetics Throughout Life: Results from a Pooled Population Analysis and Evaluation of Current Dosing Recommendations.

Pieter J ColinKarel AllegaertAlison H ThomsonDaan J TouwMichael DoltonMatthijs de HoogJason A RobertsEyob D AdaneMasato YamamotoDolores Santos-BuelgaAna Martín-SuarezNicolas SimonFabio S TacconeYoke-Lin LoEmilia BarciaMichel M R F StruysDouglas J Eleveld
Published in: Clinical pharmacokinetics (2020)
A population model was developed that is useful for further development of age and kidney function-stratified dosing regimens of vancomycin and for individualisation of treatment through therapeutic drug monitoring and Bayesian forecasting.
Keyphrases
  • methicillin resistant staphylococcus aureus
  • randomized controlled trial
  • clinical practice
  • clinical trial
  • combination therapy
  • staphylococcus aureus
  • phase iii
  • replacement therapy
  • data analysis