Antidepressant use during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder: systematic review of observational studies and methodological considerations.
Daniel R MoralesJim SlatteryStephen EvansXavier KurzPublished in: BMC medicine (2018)
Existing observational studies measuring the risk of ASD and ADHD with antidepressant exposure are heterogeneous in their design. Classical comparisons between exposed and unexposed women during pregnancy are at high risk of residual confounding. Alternative comparisons and sibling designs may aid the interpretation of causality and their utility requires further evaluation, including understanding potential limitations of undertaking meta-analyses with such data.
Keyphrases
- attention deficit hyperactivity disorder
- meta analyses
- autism spectrum disorder
- systematic review
- major depressive disorder
- intellectual disability
- randomized controlled trial
- polycystic ovary syndrome
- bipolar disorder
- pregnancy outcomes
- working memory
- emergency department
- pregnant women
- climate change
- breast cancer risk
- data analysis
- cervical cancer screening
- adipose tissue
- clinical evaluation