TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis.

Henan ZhangYi GuoHui GuXiaowei WeiWei MaDan LiuKun YuWenting LuoLing MaYusi LiuJia XueJieting HuangYanfu WangShanshan JiaNaixuan DongHongyan WangZheng Wei Yuan

Published in: Clinical epigenetics (2019)

These findings suggest that spinal cord tissues in cases with NTDs had a different genome-wide methylation pattern compared to controls. Abnormal methylation patterns in TRIM4 in immunity pathways might be involved in NTD pathogenesis. Genetic variants in TRIM4 genes only slightly contribute to the etiology of human NTDs.

Keyphrases

genome wide
dna methylation
spinal cord
gene expression
copy number
endothelial cells
spinal cord injury
neuropathic pain
induced pluripotent stem cells
pluripotent stem cells
transcription factor