Therapeutic potential of human stem cell transplantations for Vanishing White Matter: A quest for the Goldilocks graft.

Anne E J HillenPrisca S LeferinkNicole B BreeuwsmaStephanie DoovesTalia BergaglioMarjo S Van der KnaapVivi M Heine

Published in: CNS neuroscience & therapeutics (2022)

Transplantation of human glial cell populations can have therapeutic effects for VWM. For further translation to the clinic, the microenvironment in the VWM patient brain should be considered as an important moderator of cell replacement therapy.

Keyphrases

white matter
stem cells
replacement therapy
endothelial cells
cell therapy
single cell
induced pluripotent stem cells
pluripotent stem cells
smoking cessation
multiple sclerosis
spinal cord injury
mesenchymal stem cells
resting state
spinal cord
neuropathic pain
bone marrow
blood brain barrier