Midkine release during hemodialysis is predictive of hypervolemia and associates with excess (cardiovascular) mortality in patients with end-stage renal disease: a prospective study.
Sabine BrandtAnja FischerCarla KreutzeDorothea HempelXenia GornyFlorian G ScurtDelia L ŞalaruPeter BartschAnja BernhardtStefanie M Bode-BögerMatthias GirndtRoman FiedlerBerend IsermannJonathan A LindquistPeter R MertensPublished in: International urology and nephrology (2022)
Thus, for dialysis patients inadequate periprocedural midkine upregulation is linked with hypervolemia and associates with cardiovascular events.