From Birth to Weaning: A Window of Opportunity for Microbiota.
Valentina BiagioliGreta VolpedoAntonella RivaPaolo MainardiPasquale StrianoPublished in: Nutrients (2024)
(1) Background: The first 1000 days of life constitute a critical window of opportunity for microbiota development. Nutrients play a crucial role in enriching and diversifying the microbiota, derived not only from solid food but also from maternal dietary patterns during gestation. (2) Methods: We conducted a comprehensive literature review using the PubMed database, covering eleven years (2013-2023). We included English-language reviews, original research papers, and meta-analyses, while excluding case reports and letters. (3) Results: Consensus in the literature emphasizes that our interaction with a multitude of microorganisms begins in the intrauterine environment and continues throughout our lives. The existing data suggest that early nutritional education programs, initiated during pregnancy and guiding infant diets during development, may influence the shaping of the gut microbiota, promoting long-term health. (4) Conclusions: Further research is necessary in the coming years to assess potential interventions and early nutritional models aimed at modulating the pediatric microbiota, especially in vulnerable populations such as premature newborns.
Keyphrases
- meta analyses
- systematic review
- healthcare
- gestational age
- public health
- case report
- human health
- birth weight
- physical activity
- pregnant women
- mental health
- randomized controlled trial
- autism spectrum disorder
- signaling pathway
- risk assessment
- preterm infants
- heavy metals
- machine learning
- weight loss
- pregnancy outcomes
- big data
- intensive care unit
- artificial intelligence
- preterm birth
- low birth weight
- deep learning
- health information
- data analysis