Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome.

Fabienne VenetMartin CourThomas RimmeléSebastien VielHodane YonisRemy CoudereauCamille AmazPaul AbrahamCéline MonardJean-Sebastien CasalegnoKaren Brengel-PesceAnne-Claire LukaszewiczLaurent ArgaudGuillaume Monneretnull null

Published in: Critical care (London, England) (2021)

Occurrence of ARDS in response to SARS-CoV2 infection appears to be strongly associated with the intensity of immune alterations upon ICU admission of COVID-19 patients. In these critically ill patients, immune profile presents with similarities with the delayed step of immunosuppression described in bacterial sepsis.

Keyphrases

acute respiratory distress syndrome
mechanical ventilation
extracorporeal membrane oxygenation
sars cov
intensive care unit
emergency department
immune response
acute kidney injury
high intensity
dendritic cells
respiratory syndrome coronavirus
cross sectional
coronavirus disease