BRG1 interacts with GLI2 and binds Mef2c gene in a hedgehog signalling dependent manner during in vitro cardiomyogenesis.

Joel Vincent FairAnastassia VoronovaNeven BosiljcicRashida RajgaraAlexandre BlaisIlona Sylvia Skerjanc

Published in: BMC developmental biology (2016)

Thus, we propose a mechanism where HH/GLI2 regulates the expression of Mef2c by recruiting BRG1 to the Mef2c gene, most probably via chromatin remodelling, to ultimately regulate in vitro cardiomyogenesis.

Keyphrases

genome wide
copy number
poor prognosis
binding protein
gene expression
dna damage
transcription factor
dna methylation
long non coding rna
oxidative stress