Bile acids, lipid and purine metabolism involved in hepatotoxicity of first-line anti-tuberculosis drugs.
Linsheng LiuXianglian LiChenrong HuangYicong BianXiaoxue LiuJun CaoWenhao QuLiyan MiaoPublished in: Expert opinion on drug metabolism & toxicology (2020)
ATDH was involved in bile acids and lipid and purine metabolism. The BAs metabolic pathway involvement in mice was validated in TB patients. The noninvasive metabolomics approach is more systemic than routine toxicity evaluation and can be used to assess compound toxicity and the underlying mechanism.
Keyphrases
- end stage renal disease
- mycobacterium tuberculosis
- ejection fraction
- newly diagnosed
- oxidative stress
- peritoneal dialysis
- drug induced
- fatty acid
- prognostic factors
- mass spectrometry
- emergency department
- type diabetes
- skeletal muscle
- insulin resistance
- hiv infected
- high fat diet induced
- electronic health record
- antiretroviral therapy