Disruption of orbitofrontal-hypothalamic projections in a murine ALS model and in human patients.
David BayerStefano AntonucciHans-Peter MüllerRami SaadLuc DupuisVolker RascheTobias M BöckersAlbert C LudolphJan KassubekFrancesco RoselliPublished in: Translational neurodegeneration (2021)
This study provides converging murine and human data demonstrating the selective structural disruption of hypothalamic inputs in ALS as a promising factor contributing to the origin of the hypermetabolic phenotype.