Distinct osmoregulatory responses to sodium loading in patients with altered glycosaminoglycan structure: a randomized cross-over trial.

Eliane F E WenstedtJetta J OppelaarStijn BesselingNienke M G RorijeRik H G Olde EngberinkArie OosterhofToin H van KuppeveltBert-Jan H van den BornJan AtenLiffert Vogt

Published in: Journal of translational medicine (2021)

DM1 and HME patients show distinct osmoregulatory responses to sodium loading when comparing to controls with indications for reduced sodium storage capacity in DM1 patients, suggesting that intact glycosaminoglycan biosynthesis is important in sodium and water homeostasis. Trial registration These trials were registered with the Netherlands trial register with registration numbers: NTR4095 ( https://www.trialregister.nl/trial/3933 at 2013-07-29) and NTR4788 ( https://www.trialregister.nl/trial/4645 at 2014-09-12).

Keyphrases

study protocol
phase iii
phase ii
clinical trial
end stage renal disease
ejection fraction
newly diagnosed
randomized controlled trial
peritoneal dialysis
type diabetes
metabolic syndrome
patient reported
weight loss
glycemic control
cell wall