Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor.

Gabrielle KarpinskyMalgorzata A KrawczykEwa Izycka-SwieszewskaAleksandra FatygaAgnieszka BudkaWalentyna BalwierzGrazyna SobolBeata Zalewska-SzewczykMagdalena Rychlowska-PruszynskaTeresa KlepackaBozenna Dembowska-BaginskaBernarda KazanowskaAnna GabrychEwa Bien

Published in: Journal of cancer research and clinical oncology (2018)

The initial tumor tissue expression of OPN, survivin, p53 and cyclin D1 may serve as markers to predict response to naCHT in pediatric advanced MPNST. Future studies in more numerous group of patients are needed to confirm these preliminary results.

Keyphrases

peripheral nerve
poor prognosis
end stage renal disease
newly diagnosed
chronic kidney disease
prognostic factors
signaling pathway
type iii