Effect of B12 and folate deficiency in hypomethylation of Angiotensin I converting enzyme 2 gene and severity of disease among the acute respiratory distress syndrome patients.
Reza NajafipourDavood MohammadiAbdolmabood MomeniMoghbelinejad SPublished in: Journal of clinical laboratory analysis (2023)
These results for the first time indicated that among the different mechanisms of ACE-2 expression regulation, its promoter methylation is very crucial and can be affected by factors involved in one-carbon metabolisms such as B9 and B12 vitamins deficiency.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- dna methylation
- end stage renal disease
- ejection fraction
- mechanical ventilation
- genome wide
- newly diagnosed
- poor prognosis
- angiotensin converting enzyme
- prognostic factors
- gene expression
- transcription factor
- intensive care unit
- replacement therapy
- patient reported outcomes