Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity.

Radwa El-Sayed Mahmoud Marie Noha M Abd El-Fadeal Yara El-Sayed Marei Lina M Atef

Published in: Dermatology research and practice (2022)

Gene expression of CD70 and CD27 was increased in AA lesions and was associated with disease severity and activity. Thus, both molecules can be a predictor of AA severity and activity. Furthermore, the expression was reduced in non-lesional scalp areas. Thus, a lack of CD27 and CD70 expression may initially predispose to immunological dysregulation and the development of AA.

Keyphrases

gene expression
nk cells
poor prognosis
dna methylation
long non coding rna