The Pax transcription factor EGL-38 links EGFR signaling to assembly of a cell-type specific apical extracellular matrix in the Caenorhabditis elegans vulva.

Helen F Schmidt Chelsea B Darwin Meera V Sundaram

Published in: bioRxiv : the preprint server for biology (2024)

vulva apical extracellular matrix is cell-type specific Broadly transcribed Zona Pellucida domain proteins assemble in specific matricesThe Pax2/5/8 homolog EGL-38 promotes assembly of the 1° vulva cell matrixEGL-38 expression and 1° cell matrix assembly depend on EGFR signaling.

Keyphrases

extracellular matrix
small cell lung cancer
transcription factor
single cell
epidermal growth factor receptor
cell therapy
tyrosine kinase
poor prognosis
stem cells