Operation Moonshot: rapid translation of a SARS-CoV-2 targeted peptide immunoaffinity liquid chromatography-tandem mass spectrometry test from research into routine clinical use.
Jenny HällqvistDan LaneAndrew ShapanisKayleigh DavisWendy E HeywoodIvan DoykovJustyna ŚpiewakNana GhansahBrian KeevilPankaj GuptaRebekah Jukes-JonesRaj SinghDominic FoleyJohannes P C VissersRebecca PattisonSamantha FerriesRobert WardleAmy BartlettLisa J CaltonLeigh AndersonMorteza RazaviTerry PearsonMatt PopeRichard YipLeong L NgBenjamin I NicholasAlistair BaileyDan NoelR Neil DaltonSimon HealesChristopher HopleyAndrew R PittPerdita BarranDonald J L JonesKevin MillsPaul SkippRachel S CarlingPublished in: Clinical chemistry and laboratory medicine (2022)
This unique collaboration between academia, industry and the NHS enabled development, translation, and validation of a SARS-CoV-2 method in NP swabs to be achieved in 5 months. This pilot provides a model and pipeline for future accelerated development and implementation of LC-MS/MS protein/peptide assays into the routine clinical laboratory.