Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway.

Hadeel M OsamaSally Mostafa KhadrawyEl-Shaymaa El-NahassSarah I OthmanHanaa M Mohamed

Published in: Laboratory animal research (2024)

ELT and HSP showed antioxidant and anti-inflammatory effects against CBZ-induced testicular and renal toxicity, and these effects may be promoted via activating Nrf2/HO-1 and PPARγ signaling pathways.

Keyphrases

oxidative stress
signaling pathway
diabetic rats
pi k akt
induced apoptosis
dna damage
ischemia reperfusion injury
germ cell
heat shock
epithelial mesenchymal transition
insulin resistance
heat shock protein
fatty acid
heat stress
type diabetes
cell proliferation
skeletal muscle
anti inflammatory